ORF ID	TF00009 (frame 1)	Gene ID	BH13380
Position and sequences	1523533...1525452(639 aa)	Gene Name/synonym	virD4 /traG
Organism	Bartonella henselae str. Houston-1	Cluster	67 genes
Product	Type IV secretion system-coupling protein VirD4
1stcategory	P-T4SS	2ndcategory	VirD4/TraG Family
3rdcategory	Effector translocator
Function	The type IV secretion system virB/virD4 is a major virulence determinant for subversion of human endothelial cell (HEC) function. VirB-dependent changes of HEC include massive cytoskeletal rearrangements, a proinflammatory activation by nuclear factor NF-kappa-B, inhibition of early and late events of apoptosis, leading to an increased cell survival, and, at high infection doses, a cytostatic or cytotoxic effect, which interfers with a potent virB-independent mitogenic activity. These changes of HEC require the T4S coupling protein virD4 and at least one of the effector proteins bepA-G.
Miscellaneus
References	PubMed:15210978

	KEGG database
Organism	B.henselae	Gene entry	BH13380
Gene name	traG	Synonyms
Definition	conjugal transfer protein TraG
Class	Genetic Information Processing; Sorting and Degradation; Type IV secretion system [PATH:bhe03080]
Classification	Sorting and Degradation
DBLinks	GeneID 2865237 GI 49476022 UniProt Q6G2A8
	COG Clusters of Orthologous Groups of proteins
	Gene Classification Coords (size) Product U 216 .. 634 (419) Type IV secretory pathway, VirD4 components

B.henselae :  BlastP (output)

Score Expect Query coverage Subject coverage 1262 0.0 100 100

Evidence ID Name Loci start-end InterPro ID InterPro Name HMMTigr TIGR02767 TraG-Ti [ 0 - 632 ] IPR014135 Ti-type conjugative transfer system, TraG

GO	No results found !

Score Expect Coverage Query Coverage Subject Accesion Number Product (Click to view blast result) 1262 0.0 100 100 Q6G2A8 Type IV secretion system-coupling protein virD4

PHOBIUS	txt

Psort	(output)