| ORF ID | TF00815 (frame 1) |
Gene ID | lpl2616 |
| Position and sequences | 2985373...2986785(470 aa) |
Gene Name/synonym |
icmX
- |
| Organism | Legionella pneumophila Lens |
Cluster |
4 genes |
| Product | Type IV secretion system protein IcmX |
| 1stcategory | I-T4SS |
2ndcategory | Uncharacterized Protein Family IcmX |
| 3rdcategory | Effector translocator |
| Function | Component of the type IV secretion system Dot/Icm that is required for intracellular growth in human macrophages and amoebae. IcmX, an essential component of the Dot/Icm transporter, is required for L. pneumophila phagosome trafficking and intracellular growth, because is required for the formation of pores in the membrane of eukaryotic host cells. |
| Miscellaneus | IcmX was predicted as a periplasmic component of the type IVB secretion;
An N-terminal signal peptide mediates translocation of the IcmX protein into the bacterial periplasm by a sec-dependent process;
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| References |
PubMed:10858211
PubMed:17040490
PubMed:15271914
PubMed:15003709
PubMed:14715899
PubMed:12081952
PubMed:10225863
PubMed:9488381
PubMed:9465074
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