ORF ID | TF00814 (frame 1) |
Gene ID | lpg2689 |
Position and sequences | 3038599...3039999(466 aa) |
Gene Name/synonym |
icmX
- |
Organism | Legionella pneumophila subsp. pneumophila str. Philadelphia 1 |
Cluster |
4 genes |
Product | Type IV secretion system protein IcmX |
1stcategory | I-T4SS |
2ndcategory | Uncharacterized Protein Family IcmX |
3rdcategory | Effector translocator |
Function | Component of the type IV secretion system Dot/Icm that is required for intracellular growth in human macrophages and amoebae. IcmX, an essential component of the Dot/Icm transporter, is required for L. pneumophila phagosome trafficking and intracellular growth, because is required for the formation of pores in the membrane of eukaryotic host cells. |
Miscellaneus | IcmX is a potential periplasmic component of the type IVB secretion. N-terminal signal peptide mediates translocation of the IcmX protein into the bacterial periplasm by a sec-dependent process;
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References |
PubMed:10858211 
PubMed:17040490 
PubMed:15271914 
PubMed:15003709 
PubMed:14715899 
PubMed:12081952 
PubMed:10225863 
PubMed:9488381 
PubMed:9465074 
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