| ORF ID | TF00808 (frame 1) |
Gene ID | lpl2615 |
| Position and sequences | 2984918...2985373(151 aa) |
Gene Name/synonym |
icmW
- |
| Organism | Legionella pneumophila Lens |
Cluster |
4 genes |
| Product | Type IV secretion system protein IcmW |
| 1stcategory | I-T4SS |
2ndcategory | Uncharacterized Protein Family IcmW |
| 3rdcategory | Effector translocator |
| Function | Component of the type IV secretion system Dot/Icm that is required for intracellular growth in human macrophages and amoebae. IcmW and IcmS proteins interact to form a stable complex, IcmSW, that facilitates translocation of effector proteins by the Dot/Icm system, although IcmW and IcmS may retain partial activity when they are not in a complex. |
| Miscellaneus | IcmW is a cytoplasmic protein. Effector proteins that were able to bind IcmSW in vitro required icmS and icmW for efficient translocation into eukaryotic cells during L. pneumophila infection;
|
| References |
PubMed:18069892
PubMed:17040490
PubMed:15271914
PubMed:15003709
PubMed:14715899
PubMed:12081952
PubMed:10225863
PubMed:9488381
PubMed:9465074
|