| ORF ID | TF00807 (frame 1) |
Gene ID | lpg2688 |
| Position and sequences | 3038144...3038599(151 aa) |
Gene Name/synonym |
icmW
- |
| Organism | Legionella pneumophila subsp. pneumophila str. Philadelphia 1 |
Cluster |
4 genes |
| Product | Type IV secretion system protein IcmW |
| 1stcategory | I-T4SS |
2ndcategory | Uncharacterized Protein Family IcmW |
| 3rdcategory | Effector translocator |
| Function | Component of the type IV secretion system Dot/Icm that is required for intracellular growth in human macrophages and amoebae. IcmW and IcmS proteins interact to form a stable complex, IcmSW, that facilitates translocation of effector proteins by the Dot/Icm system, although IcmW and IcmS may retain partial activity when they are not in a complex. |
| Miscellaneus | IcmW is a cytoplasmic protein;
Effector proteins that were able to bind IcmSW in vitro required icmS and icmW for efficient translocation into eukaryotic cells during L. pneumophila infection;
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| References |
PubMed:18069892
PubMed:17040490
PubMed:15271914
PubMed:15003709
PubMed:14715899
PubMed:12081952
PubMed:10225863
PubMed:9488381
PubMed:9465074
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