| ORF ID | TF00775 (frame 1) |
Gene ID | AAA98081 |
| Position and sequences | 1...938(938 aa) |
Gene Name/synonym |
traG
- |
| Organism | Plasmid F |
Cluster |
7 genes |
| Product | F-type conjugal transfer protein TraG |
| 1stcategory | F-T4SS |
2ndcategory | TraG-like-F Family |
| 3rdcategory | Conjugation |
| Function | Component of the conjugative T4SS trb/tra required for the transfer of plasmid F among E. coli cells, from donor cells to recipients. The TraG is required for two stages of the conjugation process: pilus biosynthesis and mating pair stabilization (Mps). TraG is a polytopic inner-membrane protein with a large C-terminal periplasmic domain that is required for piliation and Mps, whereas the N-terminal region is sufficient for pilus synthesis.
The third function of TraG is of entry exclusion (Eex) through interaction with TraS in the recipient cell. |
| Miscellaneus | The C-terminal region of TraG is thought to be cleaved by the host signal peptidase I to give a fragment called TraG* that is responsible for Mps.
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| References |
PubMed:17259615
PubMed:7915817
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