ORF information
ORF ID TF00051 (frame 1) Gene ID BH13350
Position and sequences 1520381...1521451(356 aa) Gene Name/synonym virB11 -
Organism Bartonella henselae str. Houston-1 Cluster 206 genes
Product Type IV secretion system protein VirB11 homolog
1stcategory P-T4SS 2ndcategory VirB11/TrbB/GspE Family
3rdcategory Effector translocator
Function The type IV secretion system virB/virD4 is a major virulence determinant for subversion of human endothelial cell (HEC) function. VirB-dependent changes of HEC include massive cytoskeletal rearrangements, a proinflammatory activation by nuclear factor NF-kappa-B, inhibition of early and late events of apoptosis, leading to an increased cell survival, and, at high infection doses, a cytostatic or cytotoxic effect, which interfers with a potent virB-independent mitogenic activity. These changes of HEC require the T4S coupling protein virD4 and at least one of the effector proteins bepA-G. Together with virB4, may be implicated in providing the energy, via hydrolysis of ATP, for the assembly of secretion system and substrate transport.
Miscellaneus
References PubMed:15049812  PubMed:15642951 

Functional Annotation
  KEGG database
Organism B.henselae Gene entry BH13350
Gene name virB Synonyms 11
Definition VirB11 protein homolog
Class Genetic Information Processing; Sorting and Degradation; Type IV secretion system [PATH:bhe03080]
Classification Sorting and Degradation
DBLinks GeneID 2865824 GI 49476019 UniProt Q9RNC7
 
  COG Clusters of Orthologous Groups of proteins
 
Gene Classification Coords (size) Product
N 10 .. 354 (345) Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis

Blast results (KEGG)
B.henselae :  BlastP (output)
Score Expect Query coverage Subject coverage
698 0.0 100 100

InterPro
Evidence ID Name Loci start-end InterPro ID InterPro Name
HMMPfam PF00437 GSPII_E [ 0 - 334 ] IPR001482 Type II secretion system protein E
BlastProDom PD000739 GSPII_E [ 0 - 256 ] IPR001482 Type II secretion system protein E
HMMTigr TIGR02788 VirB11 [ 0 - 344 ] IPR014155 P-type DNA transfer ATPase VirB11

GO (Gene Onthology)
ID Type Description
0005524 Molecular Function ATP binding
0005622 Cellular Component intracellular
0006810 Biological Process transport
0005524 Molecular Function ATP binding
0005622 Cellular Component intracellular
0006810 Biological Process transport

Blast Results (Swiss-Prot)
Score Expect Coverage Query Coverage Subject Accesion Number Product (Click to view blast result)
698 0.0 100 100 Q9RNC7 Type IV secretion system protein virB11

Topology
 
PHOBIUS txt

Protein localization analysis
 
Psort bacterial inner membrane-0.1786-Affirmative (output)