| ORF ID | TF00509 (frame 1) |
Gene ID | lpl0488 |
| Position and sequences | 529093...531444(783 aa) |
Gene Name/synonym |
icmO
/dotL |
| Organism | Legionella pneumophila Lens |
Cluster |
7 genes |
| Product | Type IV secretion system protein IcmO/DotL |
| 1stcategory | I-T4SS |
2ndcategory | Uncharacterized Protein Family IcmO/DotL |
| 3rdcategory | Effector translocator |
| Function | Component of the type IV secretion system Dot/Icm that is required for intracellular growth in human macrophages and amoebae. The IcmO/DotL protein is not only required for growth of L. pneumophila inside macrophages but is also essential for viability of certain strains on bacteriological media. |
| Miscellaneus | DotL is an inner membrane protein. A model proposed by Buscher et al (2005) says that DotL play the role of a regulator of the T4SS, controlling the opening and closing of the pore. DotL contains a nucleotide binding motif and shows extensive sequence similarity to the conjugal transfer protein TrbC from IncI plasmids. Also has limited homology to a family of proposed ATPases known type IV secretion system coupling proteins (T4CPs).
|
| References |
PubMed:15838018
PubMed:17040490
PubMed:15271914
PubMed:15003709
PubMed:14715899
PubMed:12081952
PubMed:10225863
PubMed:9488381
PubMed:9465074
PubMed:10564519
|