| ORF ID | TF00508 (frame 1) |
Gene ID | lpg0446 |
| Position and sequences | 482061...484412(783 aa) |
Gene Name/synonym |
icmO
/dotL |
| Organism | Legionella pneumophila subsp. pneumophila str. Philadelphia 1 |
Cluster |
7 genes |
| Product | Type IV secretion system protein IcmO/DotL |
| 1stcategory | I-T4SS |
2ndcategory | Uncharacterized Protein Family IcmO/DotL |
| 3rdcategory | Effector translocator |
| Function | Component of the type IV secretion system Dot/Icm that is required for intracellular growth in human macrophages and amoebae. The IcmO/DotL protein is not only required for growth of L. pneumophila inside macrophages but is also essential for viability of certain strains on bacteriological media.
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| Miscellaneus | DotL is an inner membrane protein. A model proposed by Buscher et al (2005) says that DotL play the role of a regulator of the T4SS, controlling the opening and closing of the pore. DotL contains a nucleotide binding motif and shows extensive sequence similarity to the conjugal transfer protein TrbC from IncI plasmids. Also has limited homology to a family of proposed ATPases known type IV secretion system coupling proteins (T4CPs).
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| References |
PubMed:15838018
PubMed:17040490
PubMed:15271914
PubMed:15003709
PubMed:14715899
PubMed:12081952
PubMed:10225863
PubMed:9488381
PubMed:9465074
PubMed:10564519
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