ORF information
ORF ID TF00487 (frame 1) Gene ID Atu6175
Position and sequences 190241...191122(293 aa) Gene Name/synonym virB9 -
Organism Agrobacterium tumefaciens C58 UWash Cluster 67 genes
Product Type IV secretion system protein VirB9
1stcategory P-T4SS 2ndcategory VirB9/TrbG Family
3rdcategory Effector and T-DNA translocator
Function Component of the T4SS VirB/D4 required for the translocation of the virulence factors (VirE2, VirF and the VirD2-T-DNA complex) to plant cells. VirB9 is a component of an outer-membrane-associated channel complex of the T4SS VirB/D4, in wich distinct structural domains contribute to substrate selection and translocation, establishment of channel subunit contacts, and T-pilus biogenesis. VirB7 and VirB9 form a keystone interaction essential for assembly of the apparatus into a functioning secretion system.
Miscellaneus VirB7 interacts with and stabilizes VirB9, and formation of the VirB7-VirB9 heterodimer, which in turn, stabilizes other type IV components. The structure of the VirB7-VirB9 interaction provides the basis for a rational approach to the disruption of this interaction in other bacterial system. Small molecules targeted against this interaction may be useful drugs to combat human infectious diseases where T4S plays a crucial role.
References PubMed:17244707  PubMed:15866936  PubMed:8655494  PubMed:8981983 

Functional Annotation
  KEGG database
Organism A.tumefaciens_C Gene entry AGR_pTi_12
Gene name virB Synonyms 9
Definition probable virB9 gene
Class Genetic Information Processing; Sorting and Degradation; Type IV secretion system [PATH:atc03080]
Classification Sorting and Degradation
DBLinks GeneID 1142669 GI 16119791 UniProt P17799
 
  COG Clusters of Orthologous Groups of proteins
 
Gene Classification Coords (size) Product
U 19 .. 293 (275) Type IV secretory pathway, VirB9 components

Blast results (KEGG)
A.tumefaciens_C :  BlastP (output)
Score Expect Query coverage Subject coverage
583 e-165 100 100

InterPro
Evidence ID Name Loci start-end InterPro ID InterPro Name
HMMTigr TIGR02781 VirB9: P-type conjugative transfer protein V [ 0 - 268 ] IPR014148 P-type conjugative transfer protein VirB9
HMMPfam PF03524 CagX [ 0 - 267 ] IPR010258 Conjugal transfer, TrbG/VirB9/CagX
GO (Gene Onthology)
 
GO No results found !

Blast Results (Swiss-Prot)
Score Expect Coverage Query Coverage Subject Accesion Number Product (Click to view blast result)
583 e-166 100 100 P17799 Protein virB9 precursor

Topology
 
PHOBIUS txt

Protein localization analysis
 
Psort bacterial inner membrane-0.1786-Affirmative (output)