ORF ID | TF00443 (frame 1) | Gene ID | BH13270 |
Position and sequences | 1513104...1513415(103 aa) | Gene Name/synonym | virB3 - |
Organism | Bartonella henselae str. Houston-1 | Cluster | 35 genes |
Product | Type IV secretion system protein VirB3 homolog | ||
1stcategory | P-T4SS | 2ndcategory | VirB3/TrbD Family |
3rdcategory | Effector translocator | ||
Function | The type IV secretion system virB/virD4 is a major virulence determinant for subversion of human endothelial cell (HEC) function. VirB-dependent changes of HEC include massive cytoskeletal rearrangements, a proinflammatory activation by nuclear factor NF-kappa-B, inhibition of early and late events of apoptosis, leading to an increased cell survival, and, at high infection doses, a cytostatic or cytotoxic effect, which interfers with a potent virB-independent mitogenic activity. These changes of HEC require the T4S coupling protein virD4 and at least one of the effector proteins bepA-G. VirB3 may play a role in stabilization of pilus structure. | ||
Miscellaneus | VirB3 interacts with the 17 kDa antigen protein that is encoded within the virB locus. | ||
References | PubMed:15049812  PubMed:15642951  PubMed:15231811  |
KEGG database | |||
Organism | B.henselae | Gene entry | BH13270 |
Gene name | virB | Synonyms | 3 |
Definition | VirB3 protein homolog | ||
Class | Genetic Information Processing; Sorting and Degradation; Type IV secretion system [PATH:bhe03080] | ||
Classification | Sorting and Degradation | ||
DBLinks | GeneID 2865826 GI 49476011 UniProt Q9S3N1 | ||
COG | No results found ! |
B.henselae : BlastP (output) | ||||||||
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InterPro | No results found ! |
GO | No results found ! |
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PHOBIUS | txt |
Psort | bacterial inner membrane-0.2317-Affirmative (output) |