ORF information
ORF ID TF00443 (frame 1) Gene ID BH13270
Position and sequences 1513104...1513415(103 aa) Gene Name/synonym virB3 -
Organism Bartonella henselae str. Houston-1 Cluster 35 genes
Product Type IV secretion system protein VirB3 homolog
1stcategory P-T4SS 2ndcategory VirB3/TrbD Family
3rdcategory Effector translocator
Function The type IV secretion system virB/virD4 is a major virulence determinant for subversion of human endothelial cell (HEC) function. VirB-dependent changes of HEC include massive cytoskeletal rearrangements, a proinflammatory activation by nuclear factor NF-kappa-B, inhibition of early and late events of apoptosis, leading to an increased cell survival, and, at high infection doses, a cytostatic or cytotoxic effect, which interfers with a potent virB-independent mitogenic activity. These changes of HEC require the T4S coupling protein virD4 and at least one of the effector proteins bepA-G. VirB3 may play a role in stabilization of pilus structure.
Miscellaneus VirB3 interacts with the 17 kDa antigen protein that is encoded within the virB locus.
References PubMed:15049812  PubMed:15642951  PubMed:15231811 

Functional Annotation
  KEGG database
Organism B.henselae Gene entry BH13270
Gene name virB Synonyms 3
Definition VirB3 protein homolog
Class Genetic Information Processing; Sorting and Degradation; Type IV secretion system [PATH:bhe03080]
Classification Sorting and Degradation
DBLinks GeneID 2865826 GI 49476011 UniProt Q9S3N1
 
 
COG No results found !

Blast results (KEGG)
B.henselae :  BlastP (output)
Score Expect Query coverage Subject coverage
212 2e-54 100 100
InterPro
 
InterPro No results found !
GO (Gene Onthology)
 
GO No results found !

Blast Results (Swiss-Prot)
Score Expect Coverage Query Coverage Subject Accesion Number Product (Click to view blast result)
212 2e-55 100 100 Q9S3N1 Type IV secretion system protein virB3

Topology
 
PHOBIUS txt

Protein localization analysis
 
Psort bacterial inner membrane-0.2317-Affirmative (output)