ORF ID	TF00354 (frame 1)	Gene ID	BH13260
Position and sequences	1512780...1513103(107 aa)	Gene Name/synonym	virB2 -
Organism	Bartonella henselae str. Houston-1	Cluster	23 genes
Product	Type IV secretion system protein VirB2 homolog
1stcategory	P-T4SS	2ndcategory	VirB2/TrbC Family
3rdcategory	Effector translocator
Function	The type IV secretion system virB/virD4 is a major virulence determinant for subversion of human endothelial cell (HEC) function. VirB-dependent changes of HEC include massive cytoskeletal rearrangements, a proinflammatory activation by nuclear factor NF-kappa-B, inhibition of early and late events of apoptosis, leading to an increased cell survival, and, at high infection doses, a cytostatic or cytotoxic effect, which interfers with a potent virB-independent mitogenic activity. These changes of HEC require the T4S coupling protein virD4 and at least one of the effector proteins bepA-G. VirB2 seems to constitue the major pilus component.
Miscellaneus	Pobable homooligomer. VirB2 interacts with the 17 kDa antigen protein that is encoded within the virB locus.
References	PubMed:15049812  PubMed:15642951  PubMed:15231811

	KEGG database
Organism	B.henselae	Gene entry	BH13260
Gene name	virB	Synonyms	2
Definition	VirB2 protein homolog
Class	Genetic Information Processing; Sorting and Degradation; Type IV secretion system [PATH:bhe03080]
Classification	Sorting and Degradation
DBLinks	GeneID 2865825 GI 49476010 UniProt Q9R3F2
	COG Clusters of Orthologous Groups of proteins
	Gene Classification Coords (size) Product U 12 .. 106 (95) Type IV secretory pathway, VirB2 components (pilins)

B.henselae :  BlastP (output)

Score Expect Query coverage Subject coverage 204 5e-52 100 100

InterPro	No results found !

GO	No results found !

Score Expect Coverage Query Coverage Subject Accesion Number Product (Click to view blast result) 204 8e-53 100 100 Q9R3F2 Type IV secretion system protein virB2 precursor

PHOBIUS	txt

Psort	bacterial inner membrane-0.3123-Affirmative (output)