ORF information
ORF ID TF00295 (frame 1) Gene ID HP0544
Position and sequences 575155...578106(983 aa) Gene Name/synonym cagE /virB4
Organism Helicobacter pylori 26695 Cluster 68 genes
Product Type IV secretion system protein VirB4 homolog
1stcategory P-T4SS 2ndcategory VirB4/TrbE/CagE Family
3rdcategory Effector translocator
Function Component of the type IV secretion system Cag/Vir, which is enconded in the cag patogenicity island PAI. The type IV secretion system Cag/Vir translocates the immunodominant antigen CagA protein into the cytosol of gastric epithelial cells. CagE is the inner membrane-localized ATPase that may provide the energy for substrate translocation.
Miscellaneus
References PubMed:11796597 

Functional Annotation
  KEGG database
Organism H.pylori Gene entry HP0544
Gene name cag2 Synonyms 3
Definition cag pathogenicity island protein 23 (picb protein)
Class Genetic Information Processing; Sorting and Degradation; Type IV secretion system [PATH:hpy03080]
Classification Sorting and Degradation
DBLinks GeneID 900243 GI 15645170 TIGR HP0544 UniProt Q48252
 
  COG Clusters of Orthologous Groups of proteins
 
Gene Classification Coords (size) Product
U 167 .. 983 (817) Type IV secretory pathway, VirB4 components

Blast results (KEGG)
H.pylori :  BlastP (output)
Score Expect Query coverage Subject coverage
1955 0.0 100.0000 100.0000

InterPro
Evidence ID Name Loci start-end InterPro ID InterPro Name
HMMTigr TIGR00929 VirB4_CagE [ 0 - 980 ] IPR004346 CagE, TrbE, VirB component of type IV transporter system

GO (Gene Onthology)
ID Type Description
0005524 Molecular Function ATP binding

Blast Results (Swiss-Prot)
Score Expect Coverage Query Coverage Subject Accesion Number Product (Click to view blast result)
1955.0000 0.0 100.0000 100.0000 Q48252 CAG pathogenicity island protein 23 (Protein picB)

Topology
 
PHOBIUS txt

Protein localization analysis
 
Psort (output)