ORF information
ORF ID TF00282 (frame 1) Gene ID BH13280
Position and sequences 1513421...1515775(784 aa) Gene Name/synonym virB4 -
Organism Bartonella henselae str. Houston-1 Cluster 68 genes
Product Type IV secretion system protein VirB4 homolog
1stcategory P-T4SS 2ndcategory VirB4/TrbE/CagE Family
3rdcategory Effector translocator
Function The type IV secretion system virB/virD4 is a major virulence determinant for subversion of human endothelial cell (HEC) function. VirB-dependent changes of HEC include massive cytoskeletal rearrangements, a proinflammatory activation by nuclear factor NF-kappa-B, inhibition of early and late events of apoptosis, leading to an increased cell survival, and, at high infection doses, a cytostatic or cytotoxic effect, which interfers with a potent virB-independent mitogenic activity. These changes of HEC require the T4S coupling protein virD4 and at least one of the effector proteins bepA-G. Together with virB11, may be implicated in providing the energy, via hydrolysis of ATP, for the assembly of secretion system and substrate transport.
Miscellaneus VirB4 interacts with virB10.
References PubMed:15049812  PubMed:15642951 

Functional Annotation
  KEGG database
Organism B.henselae Gene entry BH13280
Gene name virB Synonyms 4
Definition VirB4 protein homolog
Class Genetic Information Processing; Sorting and Degradation; Type IV secretion system [PATH:bhe03080]
Classification Sorting and Degradation
DBLinks GeneID 2865827 GI 49476012 UniProt Q9R2W4
 
  COG Clusters of Orthologous Groups of proteins
 
Gene Classification Coords (size) Product
U 4 .. 782 (779) Type IV secretory pathway, VirB4 components

Blast results (KEGG)
B.henselae :  BlastP (output)
Score Expect Query coverage Subject coverage
1558 0.0 100.0000 100.0000

InterPro
Evidence ID Name Loci start-end InterPro ID InterPro Name
HMMTigr TIGR00929 VirB4_CagE [ 0 - 781 ] IPR004346 CagE, TrbE, VirB component of type IV transporter system

GO (Gene Onthology)
ID Type Description
0005524 Molecular Function ATP binding

Blast Results (Swiss-Prot)
Score Expect Coverage Query Coverage Subject Accesion Number Product (Click to view blast result)
1558.0000 0.0 100.0000 100.0000 Q9R2W4 Type IV secretion system protein virB4

Topology
 
PHOBIUS txt

Protein localization analysis
 
Psort (output)