ORF information
ORF ID TF00282 (frame 1) Gene ID BH13280
Position and sequences 1513421...1515775(784 aa) Gene Name/synonym virB4 -
Organism Bartonella henselae str. Houston-1 Cluster 68 genes
Product Type IV secretion system protein VirB4 homolog
1stcategory P-T4SS 2ndcategory VirB4/TrbE/CagE Family
3rdcategory Effector translocator
Function The type IV secretion system virB/virD4 is a major virulence determinant for subversion of human endothelial cell (HEC) function. VirB-dependent changes of HEC include massive cytoskeletal rearrangements, a proinflammatory activation by nuclear factor NF-kappa-B, inhibition of early and late events of apoptosis, leading to an increased cell survival, and, at high infection doses, a cytostatic or cytotoxic effect, which interfers with a potent virB-independent mitogenic activity. These changes of HEC require the T4S coupling protein virD4 and at least one of the effector proteins bepA-G. Together with virB11, may be implicated in providing the energy, via hydrolysis of ATP, for the assembly of secretion system and substrate transport.
Miscellaneus VirB4 interacts with virB10.
References PubMed:15049812  PubMed:15642951 

Functional Annotation
  KEGG database
Organism B.henselae Gene entry BH13280
Gene name virB Synonyms 4
Definition VirB4 protein homolog
Class Genetic Information Processing; Sorting and Degradation; Type IV secretion system [PATH:bhe03080]
Classification Sorting and Degradation
DBLinks GeneID 2865827 GI 49476012 UniProt Q9R2W4
  COG Clusters of Orthologous Groups of proteins
Gene Classification Coords (size) Product
U 4 .. 782 (779) Type IV secretory pathway, VirB4 components

Blast results (KEGG)
B.henselae :  BlastP (output)
Score Expect Query coverage Subject coverage
1558 0.0 100.0000 100.0000

Evidence ID Name Loci start-end InterPro ID InterPro Name
HMMTigr TIGR00929 VirB4_CagE [ 0 - 781 ] IPR004346 CagE, TrbE, VirB component of type IV transporter system

GO (Gene Onthology)
ID Type Description
0005524 Molecular Function ATP binding

Blast Results (Swiss-Prot)
Score Expect Coverage Query Coverage Subject Accesion Number Product (Click to view blast result)
1558.0000 0.0 100.0000 100.0000 Q9R2W4 Type IV secretion system protein virB4


Protein localization analysis
Psort (output)