ORF ID | TF00282 (frame 1) | Gene ID | BH13280 |
Position and sequences | 1513421...1515775(784 aa) | Gene Name/synonym | virB4 - |
Organism | Bartonella henselae str. Houston-1 | Cluster | 68 genes |
Product | Type IV secretion system protein VirB4 homolog | ||
1stcategory | P-T4SS | 2ndcategory | VirB4/TrbE/CagE Family |
3rdcategory | Effector translocator | ||
Function | The type IV secretion system virB/virD4 is a major virulence determinant for subversion of human endothelial cell (HEC) function. VirB-dependent changes of HEC include massive cytoskeletal rearrangements, a proinflammatory activation by nuclear factor NF-kappa-B, inhibition of early and late events of apoptosis, leading to an increased cell survival, and, at high infection doses, a cytostatic or cytotoxic effect, which interfers with a potent virB-independent mitogenic activity. These changes of HEC require the T4S coupling protein virD4 and at least one of the effector proteins bepA-G. Together with virB11, may be implicated in providing the energy, via hydrolysis of ATP, for the assembly of secretion system and substrate transport. | ||
Miscellaneus | VirB4 interacts with virB10. | ||
References | PubMed:15049812  PubMed:15642951  |
KEGG database | |||||||||||
Organism | B.henselae | Gene entry | BH13280 | ||||||||
Gene name | virB | Synonyms | 4 | ||||||||
Definition | VirB4 protein homolog | ||||||||||
Class | Genetic Information Processing; Sorting and Degradation; Type IV secretion system [PATH:bhe03080] | ||||||||||
Classification | Sorting and Degradation | ||||||||||
DBLinks | GeneID 2865827 GI 49476012 UniProt Q9R2W4 | ||||||||||
COG Clusters of Orthologous Groups of proteins | |||||||||||
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B.henselae : BlastP (output) | ||||||||
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PHOBIUS | txt |
Psort | (output) |