ORF ID	TF00236 (frame 1)	Gene ID	BH13300
Position and sequences	1516205...1517170(321 aa)	Gene Name/synonym	virB6 -
Organism	Bartonella henselae str. Houston-1	Cluster	67 genes
Product	Type IV secretion system protein VirB6 homolog
1stcategory	P-T4SS	2ndcategory	VirB6/TrbL Family
3rdcategory	Effector translocator
Function	The type IV secretion system virB/virD4 is a major virulence determinant for subversion of human endothelial cell (HEC) function. VirB-dependent changes of HEC include massive cytoskeletal rearrangements, a proinflammatory activation by nuclear factor NF-kappa-B, inhibition of early and late events of apoptosis, leading to an increased cell survival, and, at high infection doses, a cytostatic or cytotoxic effect, which interfers with a potent virB-independent mitogenic activity. These changes of HEC require the T4S coupling protein virD4 and at least one of the effector proteins bepA-G.
Miscellaneus	TM5:232-254
References	PubMed:15049812  PubMed:15642951

	KEGG database
Organism	B.henselae	Gene entry	BH13300
Gene name	virB	Synonyms	6
Definition	VirB protein homolog
Class	Genetic Information Processing; Sorting and Degradation; Type IV secretion system [PATH:bhe03080]
Classification	Sorting and Degradation
DBLinks	GeneID 2865828 GI 49476014 UniProt Q9RND2
	COG Clusters of Orthologous Groups of proteins
	Gene Classification Coords (size) Product U 21 .. 320 (300) Type IV secretory pathway, VirB6 components

B.henselae :  BlastP (output)

Score Expect Query coverage Subject coverage 615 e-175 100 100

InterPro	No results found !

GO	No results found !

Score Expect Coverage Query Coverage Subject Accesion Number Product (Click to view blast result) 615 e-176 100 100 Q9RND2 Type IV secretion system protein virB6

PHOBIUS	txt

Psort	bacterial inner membrane-0.2359-Affirmative (output)