ORF information
ORF ID TF00021 (frame 1) Gene ID HP0524
Position and sequences 550217...552463(748 aa) Gene Name/synonym cag5 /virD4
Organism Helicobacter pylori 26695 Cluster 67 genes
Product Type IV secretion system-coupling protein VirD4
1stcategory P-T4SS 2ndcategory VirD4/TraG Family
3rdcategory Effector translocator
Function Component of the type IV secretion system Cag/Vir, which is enconded in the cag patogenicity island PAI. The type IV secretion system Cag/Vir translocates the immunodominant antigen CagA protein into the cytosol of gastric epithelial cells. VirD4 may help to deliver the T4SS substrate to the secretion machinery.
Miscellaneus
References PubMed:11796597 

Functional Annotation
  KEGG database
Organism H.pylori Gene entry HP0524
Gene name cag5 Synonyms
Definition cag pathogenicity island protein
Class Genetic Information Processing; Sorting and Degradation; Type IV secretion system [PATH:hpy03080]
Classification Sorting and Degradation
DBLinks GeneID 899267 GI 15645150 TIGR HP0524 UniProt O25260
 
  COG Clusters of Orthologous Groups of proteins
 
Gene Classification Coords (size) Product
U 136 .. 748 (613) Type IV secretory pathway, VirD4 components

Blast results (KEGG)
H.pylori :  BlastP (output)
Score Expect Query coverage Subject coverage
1508 0.0 100 100

InterPro
Evidence ID Name Loci start-end InterPro ID InterPro Name
ProfileScan PS00018 EF_HAND_1 [ 0 - 428 ] IPR002048 Calcium-binding EF-hand
HMMPfam PF02534 TraG [ 0 - 713 ] IPR003688 TRAG protein

GO (Gene Onthology)
ID Type Description
0005509 Molecular Function calcium ion binding
0009291 Biological Process unidirectional conjugation
0016020 Cellular Component membrane

Blast Results (Swiss-Prot)
Score Expect Coverage Query Coverage Subject Accesion Number Product (Click to view blast result)
79.3 6e-14 72.9947 91.5493 Q6FYV9 Type IV secretion system-coupling protein virD4

Topology
 
PHOBIUS txt

Protein localization analysis
 
Psort (output)