ORF ID	TF00208 (frame 1)	Gene ID	BH13320
Position and sequences	1517698...1518366(222 aa)	Gene Name/synonym	virB8 -
Organism	Bartonella henselae str. Houston-1	Cluster	47 genes
Product	Type IV secretion system protein VirB8 homolog
1stcategory	P-T4SS	2ndcategory	VirB8 Family
3rdcategory	Effector translocator
Function	The type IV secretion system virB/virD4 is a major virulence determinant for subversion of human endothelial cell (HEC) function. VirB-dependent changes of HEC include massive cytoskeletal rearrangements, a proinflammatory activation by nuclear factor NF-kappa-B, inhibition of early and late events of apoptosis, leading to an increased cell survival, and, at high infection doses, a cytostatic or cytotoxic effect, which interfers with a potent virB-independent mitogenic activity. These changes of HEC require the T4S coupling protein virD4 and at least one of the effector proteins bepA-G.
Miscellaneus	Have to change start codon! VirB8 interacts with VirB9 and VirB10.
References	PubMed:15049812  PubMed:15642951  PubMed:15231811

	KEGG database
Organism	B.henselae	Gene entry	BH13320
Gene name	virB	Synonyms	8
Definition	VirB8 protein homolog
Class	Genetic Information Processing; Sorting and Degradation; Type IV secretion system [PATH:bhe03080]
Classification	Sorting and Degradation
DBLinks	GeneID 2865829 GI 49476016 UniProt Q6G2B4
	COG Clusters of Orthologous Groups of proteins
	Gene Classification Coords (size) Product U 9 .. 222 (214) Type IV secretory pathway, component VirB8

B.henselae :  BlastP (output)

Score Expect Query coverage Subject coverage 435 e-121 100 100

Evidence ID Name Loci start-end InterPro ID InterPro Name HMMPfam PF04335 VirB8 [ 0 - 217 ] IPR007430 VirB8

GO	No results found !

Score Expect Coverage Query Coverage Subject Accesion Number Product (Click to view blast result) 434 e-121 100 94.8718 Q6G2B4 Type IV secretion system protein virB8

PHOBIUS	txt

Psort	bacterial inner membrane-0.4736-Affirmative (output)