| ORF ID | TF02011 (frame 1) |
Gene ID | OTBS_0953 |
| Position and sequences | 924051...926504(817 aa) |
Gene Name/synonym |
avhB4
- |
| Organism | Orientia tsutsugamushi str. Boryong |
Cluster |
5 genes |
| Product | Type IV secretion system protein VirB4-2 homolog |
| 1stcategory | P-T4SS |
2ndcategory | VirB4/TrbE/CagE Family |
| 3rdcategory | Unknown |
| Function | VirB4-2 specific substitutions alter critical residues in the NTP-binding cleft, which is essential for the function of a T4SS ATPase.Functions in DNA uptake and release and/or conjugation cannot be ruled out. |
| Miscellaneus | Several virB and virD4 genes of O. tsutsugamushi were transcriptionally active in cultured fibroblast and macrophage cell lines as well as in experimentally infected animals. This finding suggests that the T4SS may function in Orientia and may have a significant role in pathogenesis of scrub typhus.
|
| References |
PubMed:17483455
PubMed:21458586
|