ORF information
ORF ID TF00169 (frame 1) Gene ID BH13330
Position and sequences 1518366...1519229(287 aa) Gene Name/synonym virB9 -
Organism Bartonella henselae str. Houston-1 Cluster 67 genes
Product Type IV secretion system protein VirB9 homolog
1stcategory P-T4SS 2ndcategory VirB9/TrbG Family
3rdcategory Effector translocator
Function Component of the T4SS virB/virD4, which is a major virulence determinant for subversion of human endothelial cell (HEC) function. VirB-dependent changes of HEC include massive cytoskeletal rearrangements, a proinflammatory activation by nuclear factor NF-kappa-B, inhibition of early and late events of apoptosis, leading to an increased cell survival, and, at high infection doses, a cytostatic or cytotoxic effect, which interfers with a potent virB-independent mitogenic activity. These changes of HEC require the T4S coupling protein virD4 and at least one of the effector proteins bepA-G.
Miscellaneus We have to change the start codon at one Met upstream
References PubMed:15049812  PubMed:15642951 

Functional Annotation
  KEGG database
Organism B.henselae Gene entry BH13330
Gene name virB Synonyms 9
Definition VirB9 protein homolog
Class Genetic Information Processing; Sorting and Degradation; Type IV secretion system [PATH:bhe03080]
Classification Sorting and Degradation
DBLinks GeneID 2865830 GI 49476017 UniProt Q6G2B3
 
  COG Clusters of Orthologous Groups of proteins
 
Gene Classification Coords (size) Product
U 19 .. 285 (267) Type IV secretory pathway, VirB9 components

Blast results (KEGG)
B.henselae :  BlastP (output)
Score Expect Query coverage Subject coverage
575 e-163 100 100

InterPro
Evidence ID Name Loci start-end InterPro ID InterPro Name
HMMPfam PF03524 CagX [ 0 - 259 ] IPR010258 Conjugal transfer, TrbG/VirB9/CagX
ProfileScan PS51257 PROKAR_LIPOPROTEIN [ 0 - 17 ] NULL NULL
HMMTigr TIGR02781 VirB9: P-type conjugative transfer protein V [ 0 - 260 ] IPR014148 P-type conjugative transfer protein VirB9
GO (Gene Onthology)
 
GO No results found !

Blast Results (Swiss-Prot)
Score Expect Coverage Query Coverage Subject Accesion Number Product (Click to view blast result)
575 e-164 100 99.6528 Q6G2B3 Type IV secretion system protein virB9 precursor

Topology
 
PHOBIUS txt

Protein localization analysis
 
Psort bacterial inner membrane-0.2211-Affirmative (output)