ORF information
ORF ID TF01633 (frame 1) Gene ID lpp0525
Position and sequences 571568...572353(261 aa) Gene Name/synonym icmH /dotU
Organism Legionella pneumophila Paris Cluster 4 genes
Product Type IV secretion system protein IcmH/DotU
1stcategory I-T4SS 2ndcategory IcmH/DotU Family
3rdcategory Effector translocator
Function Component of the type IV secretion system Dot/Icm that is required for intracellular growth in human macrophages and amoebae. Altogether with IcmF, icmH is required for intracellular multiplication in Acanthamoeba castellani and partially required for intracellular growth in HL-60 derived human macrophages, as well as for pore formation.
Miscellaneus
References PubMed:15155646  PubMed:17040490  PubMed:15271914  PubMed:15003709  PubMed:14715899  PubMed:12081952  PubMed:10225863  PubMed:9488381  PubMed:9465074 

Functional Annotation
  KEGG database
Organism L.pneumophila_Corby Gene entry LPC_2884
Gene name icmH Synonyms
Definition IcmH (DotU)
Classification Unassigned
DBLinks GeneID 5182662 GI 148360924
 
 
COG No results found !

Blast results (KEGG)
L.pneumophila_Corby :  BlastP (output)
Score Expect Query coverage Subject coverage
519 e-146 100 100

InterPro
Evidence ID Name Loci start-end InterPro ID InterPro Name
HMMTigr TIGR03349 IV_VI_DotU: type IV / VI secretion system [ 0 - 247 ] IPR017732 Type IV / VI secretion system, DotU
GO (Gene Onthology)
 
GO No results found !
Blast Results (Swiss-Prot)
 
Blast Results (Swiss-Prot) No results found !

Topology
 
PHOBIUS txt

Protein localization analysis
 
Psort bacterial inner membrane-0.1786-Affirmative (output)