ORF ID | TF01631 (frame 1) |
Gene ID | lpg0459 |
Position and sequences | 500626...501411(261 aa) |
Gene Name/synonym |
icmH
/dotU |
Organism | Legionella pneumophila subsp. pneumophila str. Philadelphia 1 |
Cluster |
4 genes |
Product | Type IV secretion system protein IcmH/DotU |
1stcategory | I-T4SS |
2ndcategory | IcmH/DotU Family |
3rdcategory | Effector translocator |
Function | Component of the type IV secretion system Dot/Icm that is required for intracellular growth in human macrophages and amoebae. Altogether with IcmF, icmH is required for intracellular multiplication in Acanthamoeba castellani and partially required for intracellular growth in HL-60 derived human macrophages, as well as for pore formation. |
Miscellaneus |
|
References |
PubMed:15155646 
PubMed:17040490 
PubMed:15271914 
PubMed:15003709 
PubMed:14715899 
PubMed:12081952 
PubMed:10225863 
PubMed:9488381 
PubMed:9465074 
|