ORF ID	TF00126 (frame 1)	Gene ID	BH13340
Position and sequences	1519222...1520412(396 aa)	Gene Name/synonym	virB10 -
Organism	Bartonella henselae str. Houston-1	Cluster	68 genes
Product	Type IV secretion system protein VirB10 homolog
1stcategory	P-T4SS	2ndcategory	VirB10/TrbI Family
3rdcategory	Effector translocator
Function	The type IV secretion system virB/virD4 is a major virulence determinant for subversion of human endothelial cell (HEC) function. VirB-dependent changes of HEC include massive cytoskeletal rearrangements, a proinflammatory activation by nuclear factor NF-kappa-B, inhibition of early and late events of apoptosis, leading to an increased cell survival, and, at high infection doses, a cytostatic or cytotoxic effect, which interfers with a potent virB-independent mitogenic activity. These changes of HEC require the T4S coupling protein virD4 and at least one of the effector proteins bepA-G.
Miscellaneus	VirB10 interacts with VirB4, VirB8 and VirB9.
References	PubMed:15049812  PubMed:15642951  PubMed:15231811

	KEGG database
Organism	B.henselae	Gene entry	BH13340
Gene name	virB	Synonyms	10
Definition	VirB10 protein homolog
Class	Genetic Information Processing; Sorting and Degradation; Type IV secretion system [PATH:bhe03080]
Classification	Sorting and Degradation
DBLinks	GeneID 2865823 GI 49476018 UniProt Q6G2B2
	COG Clusters of Orthologous Groups of proteins
	Gene Classification Coords (size) Product U 123 .. 385 (263) Type IV secretory pathway, VirB10 components

B.henselae :  BlastP (output)

Score Expect Query coverage Subject coverage 784 0.0 100 100

InterPro	No results found !

GO	No results found !

Score Expect Coverage Query Coverage Subject Accesion Number Product (Click to view blast result) 784 0.0 100 100 Q6G2B2 Type IV secretion system protein virB10

PHOBIUS	txt

Psort	bacterial inner membrane-0.3208-Affirmative (output)